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Soluble Uric Acid Triggers the Inflammasome and Leads to Tissue Damage In order to investigate the role of sUA in vivo , we used an obstructive nephropathy model, unilateral ureter obstruction (UUO), which causes renal fibrosis and inflammation 48

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It is contraindicated for anyone with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, due to the thyroid-related findings observed in animal studies