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Nutrition, Metabolism and Cardiovascular Diseases , 33(8), 1570-1579

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Ipamorelin mimics the hormone ghrelin at the growth hormone secretagogue receptor (GHSR-1a) on pituitary cells, triggering a pulse of growth hormone release

Unregulated melanotan I and II use has caused serious adverse effects, including rhabdomyolysis, renal infarction, and priapism

Their poor cartilage specificity and rapid clearance from the joint cavity further limit therapeutic durability