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Treatment depends on the cause and severity: oral supplementation suffices for dietary deficiency, whilst patients with pernicious anaemia or malabsorption typically require intramuscular hydroxocobalamin injections

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Proper site rotation, using room-temperature medication, inserting the needle at 90 degrees, and allowing adequate time between injections in the same area all reduce unnecessary discomfort

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10.1016/j.febslet.2005.07.049 95 HarbutM

It may also affect neurotransmitters such as dopamine and serotonin , raising interest in neurological applications