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Methodist Debakey Cardiovasc J (2018) 14:25156

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Preliminary studies in other tissues suggest that high concentrations of imeglimin may increase the expression of genes encoding respiratory chain complexes 1 and 3 [16]

Recommended Dosage in Patients with Severe Renal Impairment (eGFR of 15 to 29 mL/min/1.73 m 2) Adults and Pediatric Patients Aged 4 Years and Older with Acquired HO IMCIVREE is not recommended for use in adults and pediatric patients aged 4 years and older with acquired HO and severe renal impairment