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This preparation is contraindicated in patients who are sensitive to cobalt and/or vitamin B12

Other relevant interactions: Colchicine (used for gout) may affect B12 absorption with long-term use Chloramphenicol (rarely used antibiotic) may blunt the haematological response to B12 treatment Monitoring considerations: Patients taking loop or thiazide diuretics require careful monitoring when initiating B12 therapy in severe deficiency, due to the risk of hypokalaemia during rapid cell production

The most common side effects with topical use include mild redness, temporary stinging at application site, and initial purging (worsened appearance before improvement)

10.1136/bmj.n71 [DOI] [PMC free article] [PubMed] 18.Higgins JPT, Thomas J, Chandler J et al (2021) Cochrane handbook for systematic reviews of interventions version 6.2 19.Sterne JAC, Savovi J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomized trials

What ProHealth can point to as differentiators and these are the kinds of quality signals worth weighing when you're comparing options: Transparent, single-ingredient dosing

Let gravity and surface tension do the work