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Clinical trials show Retatrutide achieving the highest mean weight loss, followed by Tirzepatide, and then Semaglutide

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Almost every plan will cover GLP-1s when its used for diabetes, and thats been the case for several years now, said JoEllen Silvis, a principal with Mercers health and benefits practice in Connecticut

10.1101/gad.1239204 Genes Dev

As of January 1, 2026, we will no longer provide coverage of GLP-1s that share an indication of obesity or weight management for individual commercial members and small employers