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In a research context, the main limitations are the gap between animal and human data, stability sensitivity requiring proper storage, and the risk of compromised results if purity is not independently verified
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Study Design Highlights Study design: Randomized, double-blind, crossover Participants: 24 healthy adults (ages 2080) Intervention: 50 mg APS + 5 g oral L-arginine Outcomes: Arginine AUC, Cmax, Tmax