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Local aggressive behavior, rapid expansible growth, recurrence and malignant transformation were sometimes reported in literature [4, 22,23,24]

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As a positive control for 3-NT formation, brain tissue slices from control animals were incubated (1 h in CO 2 incubator) with an authentic peroxynitrite-generating compound, 3-morpholinosydnonimine hydrochloride (SIN-1

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