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Downstream Signaling Pathways Following target engagement, AOD 9604 influences intracellular signaling cascades associated with lipid metabolism

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2001 Sep;39(9):907-18

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Fibroblasts (CAFs) constitute the largest group of nonimmune cells in the TME, and there is increasing evidence that CAFs can regulate glutamine levels in the TME and thus generate energy to promote the tricarboxylic acid cycle (TCA) cycle and supply energy for cancer cell growth [12]

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