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In some embodiments, the otic formulation or composition comprises about 0.06% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

10.1016/s1474-4422(13)70261-8 23 HagenT

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Known by the names L methylfolate and 5-MTHF , this compound is bioidentical in the sense that it is the same molecular structure as the folate that is in your body right now, enabling it to go to work immediately

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Ethical approval and consent to participate The study was approved centrally by the Helsinki University Hospital Ethics Committee DNro 1/13/03/02/2016 (RYSA), registered at ClinicalTrials.gov ID NCT02882685, and reviewed by the Helsinki University Hospital Research Review Board