The SCALE clinical trials were designed to assess the effectiveness and safety of this agent for weight loss in patients with obesity or overweight (BMI 27kg/m2) with comorbidities
With this in mind, DPP-4 inhibitors represent a good choice for patients with high cardiovascular risk, but they are not a first-line consideration for cardiovascular protection compared to SGLT2 inhibitors or glucagon-like peptide-1 receptor agonists, which showed greater CV benefits [35], [27]
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Gallbladder problems , including gallstones, have also been associated with GLP-1 therapy, likely related to rapid weight loss and changes in bile composition
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PMID 24613311