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Wnt signaling pathway and its importance in cancer Three different Wnt axes have been characterized, i.e., Ca, planar cell polarity (PCP), and canonical -catenin/T cell factor 1 (TCF-1) pathways

Early studies focused on characterising the mechanism demonstrating that GHRPs act through a receptor distinct from GHRH, and that this receptor (GHS-R) is the physiological target of ghrelin, discovered only later as its endogenous ligand