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Vulnerability Nodes Under Chronic Flux Constriction Chronic reductions in nutrient inflow during GLP-1RA therapy do not simply alter energy balance but reshape the metabolic boundary conditions governing systemic homeostasis

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Journal of Cardiovascular Development and Disease, 11 (12), 377

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An increased delivery of fatty acids to skeletal muscle, as well as diminished mitochondrial oxidation, results in increased intracellular content of fatty acid metabolites such as diacylglycerol (DAG), fatty acyl-CoAs, and ceramides