Pattern 2: The Non-Responder (approximately 15% of switchers) Weight loss plateaus or slows despite escalating to Zepbound 12.5 to 15 mg May report initial response at 5 to 7.5 mg that fades by week 16 to 20 Often have underlying metabolic factors (severe insulin resistance, hypothyroidism, medications causing weight gain) For this group, the switch to tirzepatide does not solve the core problem
However, I expect that oral Wegovy sales will begin to tinker down over the coming weeks, as competition heats up
Hypertension is a common complication in patients with diabetes and can contribute to kidney damage
Alcohol adds empty calories, pauses fat-burning, disrupts blood sugar, and loosens food restraint, all of which work against the way GLP-1 medications help you lose weight
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