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The limitation of that study was the small number of patients, but the authors concluded that compared with healthy neonates, the HIE group had increased melatonin, SOD, and NO concentrations, and the combination of melatonin to therapeutic hypothermia in infants with HIE can improve neurodevelopmental outcome at 6 months of age with effective effects in reducing oxidative stress in terms of NO and SOD serum level reduction

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doi: 10.1002/DDR.70107 254 UsinSGDaramolaOO

Proven Extensively researched in clinical studies with documented sleep quality benefits, deep sleep enhancement effects, and excellent safety profiles across diverse sleep populations Safe Well-tolerated in research with minimal adverse effects, no addiction potential, no next-day drowsiness, and strong safety record making it ideal for sleep optimization protocols Questions DSIP operates through fundamentally different mechanisms compared to conventional sleep medications like benzodiazepines, Z-drugs, or sedating antihistamines