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Fulurija A, Lutz TA, Sladko K, Osto M, Wielinga PY, Bachmann MF, et al

Defective cystinosin function leads to widespread accumulation of cystine crystals in all body cells and tissues, including the thyroid gland

Many companies, including Novo and Lilly, want to overcome manufacturing and supply issues by developing oral options

Hydroxocobalamin Attaches well to transport proteins, but some may convert to inactive forms

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According to USDA Agricultural Research Service data based on NHANES, approximately 6% of adults aged 60 and older in the United States are vitamin B12 deficient, defined as plasma B12 below 148 pmol/L (2009)