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BPC-157 has been shown to upregulate the expression of Vascular Endothelial Growth Factor (VEGF)

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Saxena AR, Frias JP, Brown LS, et al

These include the POMC-derived peptides released by neighbouring keratinocytes and the neuropeptide calcitonin gene-related peptide, substance P, and neuropeptide Y released from intramucosal free nerve endings, which are in close contact with melanocytes in the basal cell layer of the epithelium

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