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More is not always better, and thoughtful protocol design often outperforms brute force approaches over time

After 2 months of the intervention, the HAD group exhibited increased concentrations of vitamins (serum retinol, alpha-tocopherol, leukocyte, and plasma ascorbate), heightened activity of antioxidant enzymes (superoxide dismutase and glutathione peroxidase), and decreased levels of oxidative stress markers (malondialdehyde and lipid hydroperoxides)

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Russell, David

Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements

Effect of synovectomy