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J., Horrobin, D

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Recent research has explored whether these drugs might offer neuroprotective benefits for Alzheimer's disease, given that GLP-1 receptors are present in brain regions involved in memory and cognition

Methods We used a combination of glucagon secretion measurements in mouse and human islets (including islets from donors with type 2 diabetes), total internal reflection fluorescence microscopy imaging of secretory granule dynamics, recordings of cytoplasmic Ca 2+ and measurements of protein kinase A activity, immunocytochemistry, in vivo physiology and GTP-binding protein dissociation studies to explore how GLP-1 exerts its inhibitory effect on glucagon secretion and the role of the metabolite GLP-1(936)

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