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Because this was an observational study in a specific clinical population, randomized clinical trials are needed before GLP-1 medications can be recommended for treating addiction, co-author Gabriel Frietze said

Clinical evidence demonstrates sustained effectiveness beyond 72 weeks, though weight loss naturally slows over time due to metabolic adaptation rather than true drug tolerance

GLP-1 medications work by mimicking the natural hormone that reduces appetite, slows digestion so you feel full longer, and helps regulate blood sugar levels

PK/PD models assess exposureresponse and steadystate dynamics [13]

heart failure with preserved ejection fraction, when the heart pumps normally but is too stiff to relax and fill properly between beats