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10.1038/nrrheum.2017.50 79 MorelF.RoussetF.Vu Chuong NguyenM.TrocmeC.GrangeL.LardyB

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The decline in GSH synthesis associated with aging combined with an increase in body burden of chemicals over a lifespan contribute to age-related hypomethylation

Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), vegans and vegetarians, people with pernicious anaemia or gastrointestinal disorders affecting absorption, and those taking certain medications such as metformin or proton pump inhibitors