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Endocrinology (2011) 152(3):82835.10.1210/en.2010-0757 145 RaoAUShaoNAslanianRGChanTYDegradoSJWangLet alDiscovery of a potent thiadiazole class of histamine H3 receptor antagonist for the treatment of diabetes

Intensity of behavioral disturbances and seizure presentation assessment After paracetamol application, intensity of progressing behavioral disturbances and seizure presentation was continuously monitored, and assessed and scored (score 0 - normal, score 1 - rearing on hind legs, shaking, 2 - sleepy, tottering walk, 3 - sleepy, tottering walk and repeatedly falling down, 4 - sleepy, tottering walk and repeatedly falling down, jerking of the extremities, 5 - lying down, generalized convulsions) at particular time points depending on the regimen used, as described before