Mulder GD, Patt LM, Sanders L, et al
In this study, we created a mouse model of fibrosarcoma, which has no reported relationship with ovaries, in B6 mice (M group) to identify the key NRTP-induced factor that impairs the ovaries and investigate the detailed functional mechanism involved
Mitochondrial dysfunction in GDM is linked with altered expression of mitochondrial fusion proteins such as mitofusin 1 (MFN1), mitofusin 2 (MFN2), and optic atrophy 1 (OPA1), which are crucial for maintaining mitochondrial integrity and function [65]
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Spindle abnormalities were minimal at early time points but increased significantly by 24 hours in untreated oocytes
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