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Pre-existing cardiovascular disease and heart failure were more prevalent among participants in the insulin group (34.6% and 14.8%) than in the other groups (25.6% and 8.7% with GLP-1RA, 23.8% and 7.6% with SGLT2i and 18.9% and 4.9% in the miscellany group, respectively) (Table 1)

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Moreover, Itaconate reduces LPS-induced pulmonary fibrosis, demonstrating its potent protective effects on lung function 314

Clinical Judgment : Monitoring decisions should be individualized based on the balance of fracture risk factors, expected weight loss, treatment duration, and patient preferences

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