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Study quality was estimated by Newcastle-Ottawa Quality Assessment Scale (NOS) and Cochrane risk of bias (RoB) version 2 tool, and publication bias was estimated through forest plots and the Eggers test

Critically, elevated fasting circulating BCAAs in obesity and insulin resistance primarily indicate impaired peripheral catabolic disposal and altered inter-organ flux, not simply excessive dietary intake

Jiang S, Li W, Zhang Y, Lin J, Huang P

& Blatt, G

Escobar, M

Some patients may achieve adequate weight loss at lower maintenance doses (5 mg or 7.5 mg) with fewer side effects than higher doses (10 mg, 12.5 mg, or 15 mg)