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As outlined in detail in the CNS portion of this chapter, the glutamate/cystine antiporter system xc() exchanges intracellular glutamate for extracellular cystine

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Treatments with the NOS inhibitor L-NAME and iNOS inhibitor GW274150 are proven to improve inflammation response, and a trend toward a reduction in synovial thickness is observed (154, 155)

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FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway