10.2337/db06-0565 [DOI] [PubMed] [Google Scholar] 205.Jensen C, Secher A, Hecksher-Sorensen J, Lu T, Barkholt P, Conradsen K, et al
45,46 GLP-1RAs GLP-1RAs result from intricate structural modifications to GLP-1, enabling them to not only replicate the pharmacological functions of GLP-1 but also impede its hydrolysis by DPP-4, thereby extending the drugs half-life
The research, published in the Journal of Endocrinology and Metabolism, found that the peptide had no effect on serum IGF-1 levels, no negative effect on carbohydrate metabolism, and no anti-AOD-9604 antibodies were detected in any patients
Samples were subjected to 10% sodium dodecyl sulfate polyacrylamide gel electrophoresis (10 mg/lane) and then transferred to a polyvinylidene difluoride membrane for immunoblotting
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