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At higher concentrations, it reduces MMP activity to prevent excessive collagen breakdown

Perhaps not surprising, this hindbrain site of action is also responsible for mediating the illness-like behaviors (e.g., nausea, conditioned taste avoidance, emesis) of systemically delivered GLP-1R agonists (43)

Berberine, fiber, and protein have research behind their support roles

Incorporating soluble fiber-rich foods in your daily diet can work synergistically with GLP-1s and improve your overall metabolic health

Metabolic syndrome increases the risk of developing cardiovascular diseases and diabetes

Front Med 8:695792 Abel ED, OShea KM, Ramasamy R (2012) Insulin resistance: metabolic mechanisms and consequences in the heart