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These cytokines promote cartilage degradation, synovial inflammation, abnormal bone remodeling, and neuropathic sensitization, collectively driving the initiation, progression, and pain associated with OA 10 .Targeted anti-inflammatory therapies represent a critical direction in OA treatment

doi: 10.1210/jc.2012-3855

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& George, C

Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management