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Mammals usually rely solely on extracellular uptake as the primary source of Cys, but some mammals also use cystathionine -lyase (CGL)-mediated cystathionine-cleavage in the transsulfuration pathway as a surrogate Cys source if System X c is blocked (Shimada and Stockwell, 2016)

At least two of the five peptides were detected in most sawfly species, whereas none in any outgroup taxon

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Iron chelation alone (deferasirox) was insufficient to reduce the burden of cardiac iron overload

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DSIP has also been implicated in the regulation of several endocrine pathways