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GLP-1R activation inhibited alcohol reward as demonstrated by reduced alcohol-induced locomotor activity, CPP and accumbal dopamine release with peripheral Ex4 administration in outbred mice (Egecioglu et al., 2012)

Given that use of GLP-1 RAs have been associated with muscle loss, an important question that remains is whether repeated GLP-1 RA use and cessation alter body composition in favour of fat mass relative to lean mass, pushing individuals with obesity closer to sarcopenic obesity

These findings suggest that Homocysteine does not cause direct neurotoxicity but enhance the sensitivity of dopaminergic neurons to the environmental toxins

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No other therapies were administered

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