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Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice

These include Alzheimers Disease, Infertility, Depression, and Diabetes

For CY 2026, we proposed to continue to assign CPT codes 0559T and 0561T to APC 5733 (Level 3 Minor Procedures) and status indicator Q1. We received public comments on this proposal

17,19,22,26 Given incomplete and inconsistent reporting, AE findings were summarized descriptively

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Nitrogen retention in catabolic states (e.g., sarcopenia)