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In addition, STZ-induced C57BL/6 mice and Park2 knockout (KO) mice were used as models, and hypoxia-inducible factor 1 subunit (HIF-1) was found to up-regulate mitophagy in DPN mice, thus exerting some therapeutic effects on DPN [169]

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Combination therapy design: optimal sequencing, dosing, and toxicity management when using resmetirom and semaglutide together (or with other classes) remains speculative yet enticing, given their complementary mechanisms