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Blood sugar benefits begin during the titration phase, but maximal A1C reduction is typically observed by month three

Real-world observations suggest that properly dosed sublingual semaglutide at therapeutic levels can produce meaningful weight loss, typically in the range of 8% to 15% body weight over 12 to 16 weeks

The main risk is hypoglycemia (dangerously low blood sugar), which can become a medical emergency

Some studies even show it slightly reduces depression symptoms

Patients with advanced liver disease, who are already at increased risk of sarcopenia, may benefit from an exercise regimen that requires lower energy expenditure and may be better for patients who cannot tolerate aerobic exercise

Semaglutide: Key Differences at a Glance What Is Semaglutide