The selectivity of the peptide is further discussed by the researchers, who suggest that senescent cells may depend more strongly on FOXO4-mediated control of p53 localization and activity, so disrupting that node might preferentially remove cells that are already operating close to an apoptotic threshold
Tandon R, Nasrallah HA, Keshavan MS
All samples were incubated with primary antibodies overnight at 4 C
Thus, combining the different botanical drugs to promote synergistic effect via the same or different pathway can be considered and investigated
doi: 10.1038/s41392-022-01078-9 272 Parker-AthillE
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