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Studies show that melanin levels return to baseline when you stop using the product

Based on these findings and PK/PD modeling, we doubled our dose to 25 mg b.i.d

That chemistry makes it hydrophilic and poorly suited for partitioning into the lipid-rich stratum corneum

Hashimoto Y, Kurita M, Aiso S et al (2009) Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor /WSX-1/gp130