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The Group-I animals received a normal diet and the rest of the groups received HFD and nicotine (1.5 mg/kg, b.wt, I.P) and water ad libitum

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Therefore, most (78%) of the clonal drivers identified by analysis of the ratio of protein altering to silent mutations from sequencing human or mouse esophagus altered cell fitness in this CRISPRCas9 screen (Fig

Human clinical data remains limited