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Tonneijck L, Muskiet MH, Smits MM, et al

However, another randomized, double-blind, placebo-controlled trial in 181 patients with diabetic neuropathy found that oral supplementation with either 600 mg/day, 1,200 mg/day, or 1,800 mg/day of lipoic acid for five weeks significantly improved neuropathic symptoms (77)

SIRT1 activation promotes numerous anti-aging effects including enhanced mitochondrial biogenesis, improved stress resistance, reduced inflammation, and activation of cellular quality control mechanisms that remove damaged proteins and organelles

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Numerous studies have demonstrated that in T2DM patients, plasma GPX4 levels are reduced, whereas ACSL4, MDH, 4-HNE, and ROS levels are significantly elevated, indicating a strong link between oxidative stress in DM and ferroptosis [59,60,61,62]

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