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FIGURE 9 Depletion of intracellular GSH by added pyocyanin was previously reported by Figures 5B,C )

Drug and chemical toxicology , 44 (3), 302309

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Brunoni AR, Santos IS, Sabbag C, Lotufo PA, Bensenor IM

The combined formulation provides a framework for studying interconnected pathways involved in tissue remodeling, cellular communication, and regenerative biochemistry relevant to mammalian models

The oral small-molecule inhibitor INCB001158 (CB-1158), targeting this axis, has entered first-inhuman phase I studies and has been explored in combination with PD-1 inhibitors, suggesting that relieving substrate depletion-driven immunosuppression is clinically feasible from a safety and pharmacodynamic perspective, although its therapeutic efficacy remains to be fully established (116)