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Tirzepatide is a dual GIP/GLP-1 receptor agonist (the active ingredient in Zepbound and Mounjaro)

By supporting fatty acid oxidation, it helps maintain heart muscle efficiency and skeletal muscle performance

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Ming X, Stein T, Brimacombe M, Johnson W, Lambert G, Wagner G

This study positions the BBS5/ mouse as a valuable model for BBS research and highlights GLP-1R agonists as a promising therapy for BBS-related obesity and metabolic dysfunction