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Some practitioners use it as part of combination approaches where its gentle mechanism complements more aggressive interventions

NNMTs role is to transfer a methyl group to nicotinamide (vitamin B3), creating 1-methylnicotinamide a reaction that consumes cellular methyl donors and depletes nicotinamide adenine dinucleotide (NAD) stores

For overall tissue repair, it's frequently paired with TB-500 (Thymosin Beta-4)

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