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James SJ, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O et al

*SMD, standardized mean difference

The article says naltrexone blocks opioid receptors in the hypothalamus, removing inhibition of pro-opiomelanocortin neurons that regulate satiety, while bupropion is a norepinephrine-dopamine reuptake inhibitor that increases alertness and reduces appetite by raising dopamine and norepinephrine in the brain's appetite-control centres

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standard therapy