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In animal models, MOTS-c restored insulin sensitivity in aged and high-fat-fed mice at the muscle level - the same tissue where late-stage GLP-1 protocols often see metabolic slowdown

Juan S, Lee JH, Won SJ, Oh S, Ha MS

The FDA continues to explain GLP-1 drugs should not be used in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2). Today, experts agree that there is no real risk of thyroid cancer associated with GLP-1 drugs

Metoclopramide has traditionally been a first-line prokinetic therapy, but this agent should be administered at the lowest effective dose and for limited periods of time due to the real risk of adverse effects