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The demonstration of cardiorenal benefits with SGLT2i in clinical trials both for participants with CKD and type 2 diabetes and for those without [23,24,25] and the updated 2022 KDIGO guidelines recommending SGLT2i as first-line therapy for patients with CKD and type 2 diabetes regardless of glycemic control [6] have likely driven a shift toward their broader use for preventive cardiorenal protection and earlier implementation for patients with type 2 diabetes

Wei J, Yang B, Wang R, et al

In contrast with other GLP-1 agonists, maternal exposure to exendin-4 resulted in an increase in pre-weaning fetal growth in one study ( The fetal effects of maternal exposure to GLP-1 agonists were marked

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Whether ipamorelin specifically causes premature epiphyseal closure in humans is unknown

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