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Excessive fat intake has previously been demonstrated in mice to increase intestinal permeability, confirmed by high levels of circulating gut-derived LPS and reduced TJ protein expression (Cani et al

Cortisol or corticosterone concentrations remain near baseline in controlled models, thereby reducing glucocorticoid-driven counterregulatory effects that may otherwise complicate analysis of musculoskeletal recovery

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In the clinical application of MRgFUS, it is critical to identify and implement the appropriate ultrasound parameters for each patient to ensure precise targeting of areas for BBB opening, preventing damage to the tissue, or excessive expansion of the microbubbles, leading to blockage of blood flow and ischemia-like effects 208