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In addition, increased ROS levels are responsible for protein oxidation that can rapidly contribute to the augmentation of OxS by directly affecting cell structure, cell signaling, and essential enzymatic metabolic processes

However, CMS announced the Medicare GLP-1 Bridge demonstration in December 2025, which will allow Medicare beneficiaries to access GLP-1 obesity medications starting July 2026 , with a longer-term BALANCE Model launching in Medicare Part D by January 2027 ( [18] )

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