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The Long R3 designation describes two structural changes

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) is a synthetic analog of naturally occurring IGF-1, a hormone your body produces primarily in the liver in response to growth hormone signaling

CJC-1295 is a GHRH (growth hormone-releasing hormone) analog

Many protocols specify administration on an empty stomach because elevated glucose can blunt the GH-release response in research models

they answer different research questions, and the choice is a design decision rather than a dosing one