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This restoration of metabolic cofactor availability enables enhanced function of NAD+-dependent enzymes including sirtuins, poly(ADP-ribose) polymerases, and various deacetylases that regulate cellular metabolism, stress responses, and aging processes

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Bayanati, M., Khosroshahi, A

37 Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Location of UGTs in the body807060 Number 81 (n=5) Number 74 (n=5)5040302010 0Concentration (pmol/mg LC-MS of UGT Proteotypic Peptides protein) UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT1A10 UGT2B4 UGT2B7 UGT2B10 UGT2B15 UGT2B17Hepatic UGTs 0 10 time (min) 20 30 Antibodies are not available for many UGTs due to high homology, nor are the ones available always very specific. mRNA supports diverse UGT2B isoform disposition in tissues

Take an alcohol prep pad and vigorously wipe both stoppers

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