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Our findings demonstrate that GPR68 downregulation exacerbates ferroptosis damage by disrupting the PI3K/Akt/Nrf2 antioxidant axis, while pharmacological activation of GPR68via the benzodiazepine Lorazepamrescues neuronal viability through this pathway

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This would tentatively suggest that GSHee exerts positive effects in brain regions such as the Klliker-Fuse and pre-Btzinger complex, which generate/control rhythmic breathing 121,122,123,124,125,126,127,128,129,130,131,132 , although to our knowledge there is no reports as to the direct effects of GSH in these neuronal complexes

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