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Possible side effects include: TRT Side Effects Elevated hematocrit (polycythemia) Acne or oily skin Fluid retention Testicular atrophy (manageable with hCG) Mood fluctuations during dose adjustments Potential fertility suppression Peptide Side Effects Injection site irritation or redness Temporary fluid retention Headaches or flushing Joint tightness (with GH-releasing peptides) Nausea (rare, more common with BPC-157) Sleep pattern adjustments Most side effects are dose-dependent and resolve with protocol adjustments

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Sermorelin uses only the first 29 amino acids of GHRH without stability modifications, giving it a ~10-minute half-life requiring nightly injection to leverage peak nocturnal GH release

doi: 10.3390/ijerph19074018 199